Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.4
Supplement Facts
Serving Size: 1 Caplet
Amount Per Serving
%DV
Organic ashwagandha powder (root)(0.2% Withanolides, 0.76 mg)
380 mg
*
Organic ashwagandha extract (root)(0.5% Withanolides, 1.4 mg)
280 mg
*
Organic ashwagandha supercriticalCO2 extract (root) (Withania somnifera) (8% Withanolides, 0.8 mg)
10 mg
*
Top Medical Research Studies
9
DHA lowers cholesterol; boosts metabolism
We aimed to investigate how docosahexaenoic acid (DHA) impacts cholesterol levels and brain glucose metabolism. In our study, we focused on aged SAMP8 mice, dividing them into two groups: a control group and one receiving DHA supplementation.
Our results revealed encouraging changes; the group that received DHA showed a decrease in total cholesterol and low-density lipoprotein cholesterol, while high-density lipoprotein cholesterol levels increased. More importantly, we observed improvements in glucose metabolism in various brain regions, including the cortex and hippocampus.
These findings suggest that DHA may help lower harmful cholesterol levels and enhance brain function by regulating specific cholesterol compounds like 27-hydroxycholesterol, which are linked to glucose metabolism. Overall, our study highlights DHA's potential in supporting heart and brain health through cholesterol management.
Our results revealed encouraging changes; the group that received DHA showed a decrease in total cholesterol and low-density lipoprotein cholesterol, while high-density lipoprotein cholesterol levels increased. More importantly, we observed improvements in glucose metabolism in various brain regions, including the cortex and hippocampus.
These findings suggest that DHA may help lower harmful cholesterol levels and enhance brain function by regulating specific cholesterol compounds like 27-hydroxycholesterol, which are linked to glucose metabolism. Overall, our study highlights DHA's potential in supporting heart and brain health through cholesterol management.
Read More
7
We aimed to understand whether docosahexaenoic acid (DHA), a key component of fish oil, has a positive impact on cholesterol levels, specifically by examining its effects on high-density lipoprotein (HDL). In our study, seven healthy individuals who had never taken fish oil before consumed daily supplements containing 1125 mg of EPA and 875 mg of DHA for 30 days. After a washout period, during which they stopped taking the supplements, we assessed changes in HDL functionality and composition.
Our results indicated that fish oil supplementation led to significant modifications in the proteins and lipid content of HDL. Notably, there was an increase in beneficial phospholipid families, such as sphingomyelins and phosphatidylcholines, which are crucial for HDL's role in cholesterol transport. We found that the capacity of HDL to efflux cholesterol, which is essential for heart health, increased after taking fish oil.
Additionally, improvements in HDL cholesterol efflux capacity were correlated with higher levels of EPA in the participants' blood. These findings suggest that DHA, through its role in fish oil, enhances HDL's ability to remove cholesterol, potentially offering cardiovascular benefits. Overall, our study highlights the transformative effects of fish oil on HDL and its cholesterol management capabilities.
Our results indicated that fish oil supplementation led to significant modifications in the proteins and lipid content of HDL. Notably, there was an increase in beneficial phospholipid families, such as sphingomyelins and phosphatidylcholines, which are crucial for HDL's role in cholesterol transport. We found that the capacity of HDL to efflux cholesterol, which is essential for heart health, increased after taking fish oil.
Additionally, improvements in HDL cholesterol efflux capacity were correlated with higher levels of EPA in the participants' blood. These findings suggest that DHA, through its role in fish oil, enhances HDL's ability to remove cholesterol, potentially offering cardiovascular benefits. Overall, our study highlights the transformative effects of fish oil on HDL and its cholesterol management capabilities.
Read More
8
We conducted a comprehensive study to understand how dietary intake of polyunsaturated fatty acids (PUFAs), particularly docosahexaenoic acid (DHA), relates to cholesterol levels among older adults. By analyzing data from a diverse group of 4,461 community-dwelling adults aged 65 and above, we aimed to uncover significant patterns in their dietary habits and health metrics.
Our findings revealed an interesting connection. We noticed that higher consumption of DHA, along with eicosapentaenoic acid (EPA), was associated with lower blood glucose levels. However, when we looked specifically at cholesterol levels, the results were less definitive.
The overall analysis showed that while there was an association between PUFA intake and blood glucose, the direct impact of DHA on cholesterol levels was not as clear. This suggests that while DHA may have benefits regarding overall blood sugar control, its specific effect on cholesterol needs further investigation to establish any significant benefits.
Considering these findings, it's essential to maintain a balanced diet rich in a variety of PUFAs, including omega-3 fatty acids like DHA, while also being mindful of overall health metrics such as blood pressure and cholesterol. As we continue to explore this topic, we recognize the need for more targeted studies to decipher the complex relationships between dietary fats and cardiovascular health.
Our findings revealed an interesting connection. We noticed that higher consumption of DHA, along with eicosapentaenoic acid (EPA), was associated with lower blood glucose levels. However, when we looked specifically at cholesterol levels, the results were less definitive.
The overall analysis showed that while there was an association between PUFA intake and blood glucose, the direct impact of DHA on cholesterol levels was not as clear. This suggests that while DHA may have benefits regarding overall blood sugar control, its specific effect on cholesterol needs further investigation to establish any significant benefits.
Considering these findings, it's essential to maintain a balanced diet rich in a variety of PUFAs, including omega-3 fatty acids like DHA, while also being mindful of overall health metrics such as blood pressure and cholesterol. As we continue to explore this topic, we recognize the need for more targeted studies to decipher the complex relationships between dietary fats and cardiovascular health.
Read More
Most Useful Reviews
9
Thyroid health
8 people found this helpful
My thyroid gland improved after being inactive, and I find it comfortable for my nerves. My medical examinations after using this product alongside shilajit are thankfully good. My cholesterol, Vitamin D, and thyroid levels are all in great shape for overall health.
Read More
7.5
Stabilised condition
4 people found this helpful
A geneticist-metabolist recommended me to buy Ashwagandha from this manufacturer for its high quality and pure composition. The oblong pill shape is very convenient, allowing for faster dissolution in the mouth for a stronger effect. Ashwagandha is an excellent adaptogen, stabilising mood and enabling quick recovery from stress. It's also used in the complex therapy of adrenal gland support. I highly recommend this product!
Read More
7.5
Blood pressure control
1 people found this helpful
I’m using it to control my high blood pressure, and it helps a lot during my hectic days at work.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8
- All Researches
9
We explored how Antarctic krill oil, particularly its key components like docosahexaenoic acid (DHA), can combat high cholesterol and obesity-related issues. Our study focused on its effects in a controlled environment using obese mice that were fed a high-fat diet.
We observed that when these mice were supplemented with krill oil, there were notable reductions in cholesterol levels and fat accumulation. It seemed to positively influence various metabolic pathways, such as those associated with cholesterol metabolism.
Specifically, DHA, along with other nutrients found in krill oil, appears to aid in lowering oxidative stress and improving cholesterol metabolism. While the benefits of DHA alone weren't isolated in this study, the overall findings suggest that krill oil may work effectively in reducing the risks tied to obesity and high cholesterol.
Overall, this research indicates that incorporating krill oil into our diets could be a promising strategy for managing cholesterol levels and supporting heart health.
We observed that when these mice were supplemented with krill oil, there were notable reductions in cholesterol levels and fat accumulation. It seemed to positively influence various metabolic pathways, such as those associated with cholesterol metabolism.
Specifically, DHA, along with other nutrients found in krill oil, appears to aid in lowering oxidative stress and improving cholesterol metabolism. While the benefits of DHA alone weren't isolated in this study, the overall findings suggest that krill oil may work effectively in reducing the risks tied to obesity and high cholesterol.
Overall, this research indicates that incorporating krill oil into our diets could be a promising strategy for managing cholesterol levels and supporting heart health.
Read More
9
DHA supplementation for cholesterol management
We explored how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, influences levels of bad cholesterol and related diabetes risk. In a comprehensive study, participants were given a daily supplement of both EPA and DHA for twelve weeks. This supplementation aimed to see if it could counteract the negative effects of low-density lipoproteins (LDL) on human adipose tissue.
The results were quite revealing. Before the intervention, we noticed a significant difference in interleukin-1 beta (IL-1β) secretion, a pro-inflammatory substance linked to higher cholesterol levels, between individuals with high and low levels of atherogenic lipoproteins (apoB). After the supplementation with EPA and DHA, this inflammatory response was significantly reduced in those with high apoB. Not only did the fatty acids inhibit IL-1β secretion triggered by LDL, but they also improved fat metabolism and insulin response.
Furthermore, we observed that the omega-3 supplementation addressed various cardiometabolic risk factors, including those related to adiposity. The study indicated that DHA, alongside EPA, plays a role in managing inflammatory responses that contribute to high cholesterol levels and diabetes risk.
In conclusion, incorporating DHA as part of omega-3 supplementation could be a valuable strategy for those with elevated cholesterol levels, especially in preventing type 2 diabetes and its associated health issues.
The results were quite revealing. Before the intervention, we noticed a significant difference in interleukin-1 beta (IL-1β) secretion, a pro-inflammatory substance linked to higher cholesterol levels, between individuals with high and low levels of atherogenic lipoproteins (apoB). After the supplementation with EPA and DHA, this inflammatory response was significantly reduced in those with high apoB. Not only did the fatty acids inhibit IL-1β secretion triggered by LDL, but they also improved fat metabolism and insulin response.
Furthermore, we observed that the omega-3 supplementation addressed various cardiometabolic risk factors, including those related to adiposity. The study indicated that DHA, alongside EPA, plays a role in managing inflammatory responses that contribute to high cholesterol levels and diabetes risk.
In conclusion, incorporating DHA as part of omega-3 supplementation could be a valuable strategy for those with elevated cholesterol levels, especially in preventing type 2 diabetes and its associated health issues.
Read More
9
DHA lowers cholesterol; boosts metabolism
We aimed to investigate how docosahexaenoic acid (DHA) impacts cholesterol levels and brain glucose metabolism. In our study, we focused on aged SAMP8 mice, dividing them into two groups: a control group and one receiving DHA supplementation.
Our results revealed encouraging changes; the group that received DHA showed a decrease in total cholesterol and low-density lipoprotein cholesterol, while high-density lipoprotein cholesterol levels increased. More importantly, we observed improvements in glucose metabolism in various brain regions, including the cortex and hippocampus.
These findings suggest that DHA may help lower harmful cholesterol levels and enhance brain function by regulating specific cholesterol compounds like 27-hydroxycholesterol, which are linked to glucose metabolism. Overall, our study highlights DHA's potential in supporting heart and brain health through cholesterol management.
Our results revealed encouraging changes; the group that received DHA showed a decrease in total cholesterol and low-density lipoprotein cholesterol, while high-density lipoprotein cholesterol levels increased. More importantly, we observed improvements in glucose metabolism in various brain regions, including the cortex and hippocampus.
These findings suggest that DHA may help lower harmful cholesterol levels and enhance brain function by regulating specific cholesterol compounds like 27-hydroxycholesterol, which are linked to glucose metabolism. Overall, our study highlights DHA's potential in supporting heart and brain health through cholesterol management.
Read More
8
We investigated the connection between docosahexaenoic acid (DHA) levels and endothelial function in patients with coronary artery disease (CAD) who were already on statin therapy aimed at lowering their low-density lipoprotein cholesterol (LDL-C) levels. The goal was to see how DHA, alongside eicosapentaenoic acid (EPA), could influence cholesterol management and improve blood vessel function.
The study involved 150 patients with CAD, focusing on their serum levels of omega-3 fatty acids and their ability to maintain healthy endothelial function through a measurement called flow-mediated dilation (FMD). While we noted an association between DHA levels and endothelial dysfunction, the findings indicated that DHA alone was not assessed separately; rather, it was evaluated in tandem with EPA.
Interestingly, when we administered additional EPA to patients who had low EPA/arachidonic acid (AA) levels, there was a notable improvement in their endothelial function after three months. However, our observations suggested that while DHA levels were related to overall endothelial health, the study did not quantify the specific impact of DHA alone on cholesterol levels, leaving some questions unanswered. This highlights the complexity of omega-3 fatty acids’ effects in managing high cholesterol.
The study involved 150 patients with CAD, focusing on their serum levels of omega-3 fatty acids and their ability to maintain healthy endothelial function through a measurement called flow-mediated dilation (FMD). While we noted an association between DHA levels and endothelial dysfunction, the findings indicated that DHA alone was not assessed separately; rather, it was evaluated in tandem with EPA.
Interestingly, when we administered additional EPA to patients who had low EPA/arachidonic acid (AA) levels, there was a notable improvement in their endothelial function after three months. However, our observations suggested that while DHA levels were related to overall endothelial health, the study did not quantify the specific impact of DHA alone on cholesterol levels, leaving some questions unanswered. This highlights the complexity of omega-3 fatty acids’ effects in managing high cholesterol.
Read More
8
We explored how docosahexaenoic acid (DHA), sourced from Schizochytrium algae, affects cholesterol levels and overall egg quality in laying quails. In a study involving 1,288 Chinese yellow-feathered quails, we divided them into four groups to test different diets: a control group without DHA, and three groups with varying amounts of algae supplement (SAP and SAO).
Our observations revealed that adding 3.2% SAP significantly lowered the total cholesterol and high-density lipoprotein cholesterol (HDL-C) levels in the quails' serum. This suggests that DHA can play a role in improving lipid metabolism, potentially helping to manage cholesterol levels.
However, we found that while DHA had a positive effect on cholesterol levels, the combination of supplements used in the study makes it challenging to isolate its impact distinctively. It's essential to consider this factor in interpreting our findings, as the overall benefits were observed alongside various dietary changes.
Our observations revealed that adding 3.2% SAP significantly lowered the total cholesterol and high-density lipoprotein cholesterol (HDL-C) levels in the quails' serum. This suggests that DHA can play a role in improving lipid metabolism, potentially helping to manage cholesterol levels.
However, we found that while DHA had a positive effect on cholesterol levels, the combination of supplements used in the study makes it challenging to isolate its impact distinctively. It's essential to consider this factor in interpreting our findings, as the overall benefits were observed alongside various dietary changes.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Thyroid health
8 people found this helpful
My thyroid gland improved after being inactive, and I find it comfortable for my nerves. My medical examinations after using this product alongside shilajit are thankfully good. My cholesterol, Vitamin D, and thyroid levels are all in great shape for overall health.
Read More
7.5
Stabilised condition
4 people found this helpful
A geneticist-metabolist recommended me to buy Ashwagandha from this manufacturer for its high quality and pure composition. The oblong pill shape is very convenient, allowing for faster dissolution in the mouth for a stronger effect. Ashwagandha is an excellent adaptogen, stabilising mood and enabling quick recovery from stress. It's also used in the complex therapy of adrenal gland support. I highly recommend this product!
Read More
7.5
Blood pressure control
1 people found this helpful
I’m using it to control my high blood pressure, and it helps a lot during my hectic days at work.
Read More
Frequently Asked Questions
9
Thyroid health
8 people found this helpful
My thyroid gland improved after being inactive, and I find it comfortable for my nerves. My medical examinations after using this product alongside shilajit are thankfully good. My cholesterol, Vitamin D, and thyroid levels are all in great shape for overall health.
7.5
Stabilised condition
4 people found this helpful
A geneticist-metabolist recommended me to buy Ashwagandha from this manufacturer for its high quality and pure composition. The oblong pill shape is very convenient, allowing for faster dissolution in the mouth for a stronger effect. Ashwagandha is an excellent adaptogen, stabilising mood and enabling quick recovery from stress. It's also used in the complex therapy of adrenal gland support. I highly recommend this product!
7.5
Blood pressure control
1 people found this helpful
I’m using it to control my high blood pressure, and it helps a lot during my hectic days at work.
8
We explored whether docosahexaenoic acid (DHA), found in algal oil, can help improve cholesterol levels and reduce the risks associated with high cholesterol. The study examined the effects of both DHA-rich algal oil and palmitoleic acid-rich sea buckthorn oil on hyperlipidemia—a condition marked by high levels of fats in the blood.
In our research, we observed that DHA oil effectively regulated lipid metabolism through specific signaling pathways, helping to lower cholesterol accumulation and reduce inflammation. When administered to mice with high-fat diets, the DHA showed promising results in improving lipid profiles and promoting better liver health.
Interestingly, we also found that combining the effects of DHA with the omega-7 fatty acids from sea buckthorn oil resulted in even more significant benefits. This combination displayed a synergistic effect, enhancing the overall efficacy compared to when each oil was used alone.
Overall, the findings suggest that DHA, especially when combined with omega-7 fatty acids, can serve as a valuable dietary supplement for managing cholesterol levels. It indicates a natural approach to tackling high cholesterol and related cardiovascular conditions.
In our research, we observed that DHA oil effectively regulated lipid metabolism through specific signaling pathways, helping to lower cholesterol accumulation and reduce inflammation. When administered to mice with high-fat diets, the DHA showed promising results in improving lipid profiles and promoting better liver health.
Interestingly, we also found that combining the effects of DHA with the omega-7 fatty acids from sea buckthorn oil resulted in even more significant benefits. This combination displayed a synergistic effect, enhancing the overall efficacy compared to when each oil was used alone.
Overall, the findings suggest that DHA, especially when combined with omega-7 fatty acids, can serve as a valuable dietary supplement for managing cholesterol levels. It indicates a natural approach to tackling high cholesterol and related cardiovascular conditions.
8
We explored the effects of docosahexaenoic acid (DHA) on cholesterol levels, based on a systematic review of randomized controlled trials. This research focused on the potential cardiovascular benefits of DHA, particularly its impact on high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol levels.
According to the findings, DHA is effective in raising HDL cholesterol, which is considered protective against heart disease. In fact, DHA appears to have a greater impact, compared to its counterpart, eicosapentaenoic acid (EPA). Interestingly, while DHA may also elevate LDL cholesterol levels, it simultaneously increases the size of LDL particles, making them less harmful.
Furthermore, DHA was found to contribute to lowering heart rate and blood pressure, which are key factors for cardiovascular health. The research highlighted that both EPA and DHA positively influence platelet function and reduce oxidative stress and inflammation, further supporting heart health.
Although the results show that DHA has a series of beneficial effects, the information on its role in cholesterol management needed to be more definitive. More high-quality research is warranted to establish the comprehensive impact of DHA on cholesterol and other cardiovascular risk factors.
According to the findings, DHA is effective in raising HDL cholesterol, which is considered protective against heart disease. In fact, DHA appears to have a greater impact, compared to its counterpart, eicosapentaenoic acid (EPA). Interestingly, while DHA may also elevate LDL cholesterol levels, it simultaneously increases the size of LDL particles, making them less harmful.
Furthermore, DHA was found to contribute to lowering heart rate and blood pressure, which are key factors for cardiovascular health. The research highlighted that both EPA and DHA positively influence platelet function and reduce oxidative stress and inflammation, further supporting heart health.
Although the results show that DHA has a series of beneficial effects, the information on its role in cholesterol management needed to be more definitive. More high-quality research is warranted to establish the comprehensive impact of DHA on cholesterol and other cardiovascular risk factors.
References
- Yunoki K, Matsumi H, Miyoshi T, Kubo M, Hata Y, et al. Clinical Significance of Serum Omega-3 Fatty Acids on Endothelial Function in Patients with Coronary Artery Disease Under Statin Therapy. J Cardiovasc Dev Dis. 2025;12. doi:10.3390/jcdd12020060
- Chang Y, Xuan Y, Zhang R, Ding X, Zeng Q, et al. Effects of Dietary Schizochytrium Algae as ω-3 PUFA Source on the Egg-Laying Quail Performance, Serum Indexes, and Egg Yolk Fatty Acids Contents. Animals (Basel). 2024;15. doi:10.3390/ani15010021
- Li J, Guo J, Yuen M, Yuen H, Peng Q. The comparative effects of ω-7 fatty acid-rich sea buckthorn oil and ω-3 fatty acid-rich DHA algal oil on improving high-fat diet-induced hyperlipidemia. Food Funct. 2025;16:1241. doi:10.1039/d4fo04961f
- Coelho-Júnior HJ, Álvarez-Bustos A, Picca A, Calvani R, Rodriguez-Mañas L, et al. Dietary Intake of Polyunsaturated Fatty Acids Is Associated with Blood Glucose and Diabetes in Community-Dwelling Older Adults. Nutrients. 2024;16. doi:10.3390/nu16234087
- Cabrita ARJ, Barroso C, Fontes-Sousa AP, Correia A, Teixeira L, et al. Assessing functional properties of diet protein hydrolysate and oil from fish waste on canine immune parameters, cardiac biomarkers, and fecal microbiota. Front Vet Sci. 2024;11:1449141. doi:10.3389/fvets.2024.1449141
- Choi JH, Park SE, Kim S. Antarctic Krill Oil Supplementation Attenuates Hypercholesterolemia, Fatty Liver, and Oxidative Stress in Diet-Induced Obese Mice. Nutrients. 2024;16. doi:10.3390/nu16213614
- Lamantia V, Bissonnette S, Beaudry M, Cyr Y, Rosiers CD, et al. EPA and DHA inhibit LDL-induced upregulation of human adipose tissue NLRP3 inflammasome/IL-1β pathway and its association with diabetes risk factors. Sci Rep. 2024;14:27146. doi:10.1038/s41598-024-73672-6
- Choi GY, Calder PC. The differential effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors: an updated systematic review of randomized controlled trials. Front Nutr. 2024;11:1423228. doi:10.3389/fnut.2024.1423228
- Zhang D, Wang Z, Guo S, Sun Y, Zhou D, et al. F-Fluorodeoxyglucose positron emission tomography/computed tomography imaging reveals the protective effect of docosahexaenoic acid on glucose metabolism by reducing brain 27-hydroxycholesterol. Exp Gerontol. 2024;196:112577. doi:10.1016/j.exger.2024.112577
- Zhao W, Wang Y, Li J, Chen T, Yin D, et al. Efficacy and safety of omega-3-acid ethyl acetate 90 capsules in severe hypertriglyceridemia: A randomized, controlled, multicenter study. Lipids. 2024;59:145. doi:10.1002/lipd.12406
- Li P, Khan S, Huang Y, Lu S, Zhou P, et al. Effect of Perilla seeds inclusion on the performance, egg quality characteristics, biochemical parameters and egg yolk fatty acid composition of laying hens. Trop Anim Health Prod. 2024;56:147. doi:10.1007/s11250-024-03983-3
- Kobayashi Y, Fujikawa T, Haruna A, Kawano R, Ozawa M, et al. Omega-3 Fatty Acids Reduce Remnant-like Lipoprotein Cholesterol and Improve the Ankle-Brachial Index of Hemodialysis Patients with Dyslipidemia: A Pilot Study. Medicina (Kaunas). 2023;60. doi:10.3390/medicina60010075
- Mueller PA, Bergstrom P, Rosario S, Heard M, Pamir N. Fish Oil Supplementation Modifies the Proteome, Lipidome, and Function of High-Density Lipoprotein: Findings from a Trial in Young Healthy Adults. J Nutr. 2024;154:1130. doi:10.1016/j.tjnut.2024.01.007
